Dextromethorphan improves levodopa-induced dyskinesias in Parkinson's disease.
Neurology
; 51(1): 203-6, 1998 Jul.
Article
de En
| MEDLINE
| ID: mdl-9674803
ABSTRACT
OBJECTIVE:
This study assessed the effects of the N-methyl-D-aspartate (NMDA) antagonist dextromethorphan (DM) on levodopa-induced dyskinesias in Parkinson's disease (PD).BACKGROUND:
Recent experimental evidence suggests that increased synaptic efficacy of NMDA receptors expressed on basal ganglia neurons may play a role in the pathophysiology of levodopa-induced motor response complications.METHODS:
DM was given to six PD patients with motor fluctuations in a double-blind, placebo-controlled, cross-over study. At the end of each 3-week study arm, patients received several brief i.v. levodopa infusions while parkinsonian symptoms and dyskinesias were frequently scored. Levodopa dose-response curves for antiparkinsonian and dyskinetic effects were then compared for each study arm.RESULTS:
With DM, average and maximum dyskinesia scores improved by >50%, without compromising the antiparkinsonian response magnitude or duration of levodopa, although in some subjects the levodopa threshold dose was slightly higher with DM than with placebo.CONCLUSIONS:
These findings support the view that drugs acting to inhibit glutamatergic transmission at the NMDA receptors can ameliorate levodopa-associated dyskinesias.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antitussifs
/
Maladie de Parkinson
/
Lévodopa
/
Dextrométhorphane
/
Dyskinésie due aux médicaments
/
Antiparkinsoniens
Type d'étude:
Clinical_trials
Limites:
Aged
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Neurology
Année:
1998
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique