The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques.
J Exp Med
; 188(6): 1159-71, 1998 Sep 21.
Article
de En
| MEDLINE
| ID: mdl-9743534
ABSTRACT
CD4+ T lymphocyte depletion in human immunodeficiency virus type 1 (HIV-1)-infected humans underlies the development of acquired immune deficiency syndrome. Using a model in which rhesus macaques were infected with chimeric simian-human immunodeficiency viruses (SHIVs), we show that both the level of viremia and the structure of the HIV-1 envelope glycoprotein ectodomains individually contributed to the efficiency with which CD4(+) T lymphocytes were depleted. The envelope glycoproteins of recombinant SHIVs that efficiently caused loss of CD4(+) T lymphocytes exhibited increased chemokine receptor binding and membrane-fusing capacity compared with those of less pathogenic viruses. These studies identify the HIV-1 envelope glycoprotein ectodomains as determinants of CD4(+) T lymphocyte loss in vivo and provide a foundation for studying pathogenic mechanisms.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lymphocytes T CD4/
/
Protéines de l'enveloppe virale
/
Syndrome d'immunodéficience acquise du singe
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Déplétion lymphocytaire
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Exp Med
Année:
1998
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique