Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules.
Biochemistry
; 37(40): 14204-12, 1998 Oct 06.
Article
de En
| MEDLINE
| ID: mdl-9760258
ABSTRACT
TAR RNA represents an attractive target for the intervention of human immunodeficiency virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule inhibitors of the HIV-1 Tat-TAR interaction that target the RNA, not the protein. The chemical structures and RNA binding characteristics of these inhibitors are unique for each molecule. Results from various biochemical and spectroscopic methods reveal that each of the three Tat-TAR inhibitors recognizes a different structural feature at the bulge, lower stem, or loop region of TAR. Furthermore, one of these Tat-TAR inhibitors has been demonstrated, in cellular environments, to inhibit (a) a TAR-dependent, Tat-activated transcription and (b) the replication of HIV-1 in a latently infectious model.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
ARN viral
/
Répétition terminale longue du VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Protéines de liaison à l'ARN
/
Agents antiVIH
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Biochemistry
Année:
1998
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique