Captopril inhibits both dopaminergic and cholinergic neurotransmission in the central nervous system.
Clin Exp Pharmacol Physiol
; 25(11): 904-7, 1998 Nov.
Article
de En
| MEDLINE
| ID: mdl-9807661
ABSTRACT
1. The present study was performed to investigate the effects of captopril on both dopaminergic and cholinergic neurotransmission in the rat central nervous system. 2. Slices of rat striatum were prepared and prelabelled with [3H]-dopamine or [3H]-choline. Slices were continuously superfused with Krebs'-Ringer solution and electrical stimulation (1 Hz) was performed. 3. Captopril significantly inhibited stimulation-evoked [3H]-dopamine release from rat striatal slices in a concentration-dependent manner (S2/S1 ratios control 0.835 +/- 0.018 (n = 6); 1 x 10(-5) mol/L captopril 0.597 +/- 0.035 (n = 6; P < 0.05); 5 x 10(-5) mol/L captopril 0.561 +/- 0.041 (n = 6; P < 0.05)). However, the basal release of [3H]-dopamine was not affected by captopril. 4. Captopril also reduced stimulation-evoked [3H]-acetylcholine release in the striatum (S2/S1 ratios control 0.891 +/- 0.016 (n = 6); 1 x 10(-5) mol/L captopril 0.794 +/- 0.011 (n = 6; P < 0.05)). 5. These results show that captopril inhibits the release of both dopamine and acetylcholine in the rat striatum. Although the mechanisms underlying the neurosuppressive effects of captopril remain to be determined, the findings suggest that the inhibition of dopaminergic and cholinergic neurotransmission may be related to the central action of the angiotensin-converting enzyme inhibitor.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Inhibiteurs de l'enzyme de conversion de l'angiotensine
/
Captopril
/
Dopamine
/
Système nerveux central
/
Neurofibres cholinergiques
/
Transmission synaptique
/
Antihypertenseurs
Limites:
Animals
Langue:
En
Journal:
Clin Exp Pharmacol Physiol
Année:
1998
Type de document:
Article
Pays d'affiliation:
Japon