A non-randomized comparison of two radiotherapy protocols in inoperable squamous cell carcinoma of the oesophagus.
Clin Oncol (R Coll Radiol)
; 10(5): 306-12, 1998.
Article
de En
| MEDLINE
| ID: mdl-9848331
ABSTRACT
We report an audit of two different telebrachytherapy schedules in inoperable carcinoma of the oesophagus. Between October 1990 and December 1996, 108 patients with a Karnofsky performance status > or = 50 were selected from our database on the basis of intention to treat by telebrachytherapy. Teletherapy in the low dose group L (55 patients) consisted of 35 Gy in 15 fractions over 3 weeks, while that in the high dose group H (53 patients) consisted of 50 Gy in 25 fractions over 5 weeks. The choice of teletherapy dose was based on physician preference. The high dose rate intraluminal radiotherapy that followed 2 weeks later was identical in both groups and consisted of two applications of 6 Gy, a week apart. The pretreatment disease characteristics of the patients in both arms were similar. Relief of dysphagia was obtained in 49% of the patients in group L and in 75% of those in group H (chi2 P = 0.004). The median dysphagia-free interval was 0 and 7 months in groups L and H respectively (log-rank P = 0.06), while the median overall survival was identical at 8 months (log-rank P = 0.21) for both groups. The probability of survival at 1, 2 and 5 years was 34.8% versus 35.8%, 14.5% versus 13.9% and 0% versus 10% for groups L and H respectively. Morbidity in the form of ulcers, strictures and fistulae were observed in 9%, 7% and 5% of patients in group L compared with 8%, 8% and 13% in groups H respectively. This audit suggests that the protocol used in group H, when compared with group L, results in a greater proportion of patients being rendered dysphagia free, with a statistical trend towards a greater sustainment of dysphagia relief on follow-up.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Soins palliatifs
/
Curiethérapie
/
Tumeurs de l'oesophage
/
Carcinome épidermoïde
Type d'étude:
Observational_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Clin Oncol (R Coll Radiol)
Sujet du journal:
NEOPLASIAS
Année:
1998
Type de document:
Article
Pays d'affiliation:
Inde