Human T cell lymphotropic virus: necessity for and feasibility of a vaccine
Ciba Found Symp
; 187: 47-55, 1994.
Article
de En
| MedCarib
| ID: med-4730
Bibliothèque responsable:
JM3.1
Localisation: JM3.1; Reprint Collection
ABSTRACT
Human T cell lymphotropic virus types I and II (HTLV-I/II) are endemic in certain areas of the world. The cause two life-threatening diseases, adult T cell leukaemia/lymphoma and tropical spastic paraparesis. A vaccine is needed because in developing countries there are no other feasible preventive interventions against these diseases and in Western countries intravenous drug users at high risk for HTLV-I and HTLV-II infections and the health workers in contact with such populations must be protected. We have developed a rat model in which we observed variations of susceptibility to viral infection between inbred strains, the most susceptible being Fischer F344, and the possibility of viral latency in the nervous system. We have prepared a recombinant adenovirus vector that expresses the HTLV-I envelope glycoprotein env in HeLa cells. A target human population in French Guyana, in which the prevalence rate reaches 5.6 percent in one ethnic group (Bonis), has been identified for possible intervention (AU)
Recherche sur Google
Collection:
01-internacional
Base de données:
MedCarib
Sujet principal:
Vaccins antiviraux
/
Vaccins synthétiques
/
Virus T-lymphotrope humain de type 1
/
Infections à HTLV-I
/
Virus T-lymphotrope humain de type 2
/
Infections à HTLV-II
Type d'étude:
Risk_factors_studies
Limites:
Humans
Langue:
En
Journal:
Ciba Found Symp
Année:
1994
Type de document:
Article