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Neutralization of SARS-CoV-2 variants by convalescent and vaccinated serum
Timothy A. Bates; Hans C Leier; Zoe L Lyski; Savannah K McBride; Felicity J Coulter; Jules B Weinstein; James R Goodman; Zhengchun Lu; Sarah A. R. Siegel; Peter Sullivan; Matt Strnad; Amanda E Brunton; David X Lee; Marcel E Curlin; William B Messer; Fikadu G Tafesse.
Affiliation
  • Timothy A. Bates; Oregon Health & Science University
  • Hans C Leier; Oregon Health & Science University
  • Zoe L Lyski; Oregon Health & Science University
  • Savannah K McBride; Oregon Health & Science University
  • Felicity J Coulter; Oregon Health & Science University
  • Jules B Weinstein; Oregon Health & Science University
  • James R Goodman; Oregon Health & Science University
  • Zhengchun Lu; Oregon Health & Science University
  • Sarah A. R. Siegel; Oregon Health & Science University
  • Peter Sullivan; Oregon Health & Science University
  • Matt Strnad; Oregon Health & Science University
  • Amanda E Brunton; Oregon Health & Science University
  • David X Lee; Oregon Health & Science University
  • Marcel E Curlin; Oregon Health & Science University
  • William B Messer; Oregon Health & Science University
  • Fikadu G Tafesse; Oregon Health & Science University
Preprint de En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21254881
ABSTRACT
We tested human sera from large, demographically balanced cohorts of BNT162b2 vaccine recipients (n=51) and COVID-19 patients (n=44) for neutralizing antibodies against SARS-CoV-2 variants B.1.1.7 and B.1.351. Although the effect is more pronounced in the vaccine cohort, both B.1.1.7 and B.1.351 show significantly reduced levels of neutralization by vaccinated and convalescent sera. Age is negatively correlated with neutralization in vaccinee, and levels of variant-specific RBD antibodies are proportional to neutralizing activities.
Licence
cc_by_nc
Texte intégral: 1 Collection: 09-preprints Base de données: PREPRINT-MEDRXIV Type d'étude: Cohort_studies / Observational_studies / Prognostic_studies Langue: En Année: 2021 Type de document: Preprint
Texte intégral: 1 Collection: 09-preprints Base de données: PREPRINT-MEDRXIV Type d'étude: Cohort_studies / Observational_studies / Prognostic_studies Langue: En Année: 2021 Type de document: Preprint