Cet article est une Preprint
Les preprints sont des rapports de recherche préliminaires qui n'ont pas été certifiés par l’évaluation par les pairs. Ils ne devraient pas être considérés comme guidant la pratique clinique ou les comportements liés à la santé et ne devraient pas être rapportés dans les médias comme des informations établies.
Les preprints publiées en ligne permettent aux auteurs de recevoir des commentaires rapidement, et toute la communauté scientifique peut évaluer indépendamment le travail et répondre en conséquence. Ces commentaires sont publiés avec les preprints que quiconque peut lire et servir d’évaluation post-publication.
Risk factors for long COVID: analyses of 10 longitudinal studies and electronic health records in the UK
Preprint
de En
| PREPRINT-MEDRXIV
| ID: ppmedrxiv-21259277
ABSTRACT
BackgroundThe impact of long COVID is considerable, but risk factors are poorly characterised. We analysed symptom duration and risk factor from 10 longitudinal study (LS) samples and electronic healthcare records (EHR). MethodsSamples 6907 adults self-reporting COVID-19 infection from 48,901 participants in the UK LS, and 3,327 adults with COVID-19, were assigned a long COVID code from 1,199,812 individuals in primary care EHR. Outcomes for LS included symptom duration lasting 4+ weeks (long COVID) and 12+ weeks. Association with of age, sex, ethnicity, socioeconomic factors, smoking, general and mental health, overweight/obesity, diabetes, hypertension, hypercholesterolaemia, and asthma was assessed. ResultsIn LS, symptoms impacted normal functioning for 12+ weeks in 1.2% (mean age 20 years) to 4.8% (mean age 63 y) of COVID-19 cases. Between 7.8% (mean age 28 y) and 17% (mean age 58 y) reported any symptoms for 12+ weeks, and greater proportions for 4+ weeks. Age was associated with a linear increased risk in long COVID between 20 and 70 years. Being female (LS OR=1.49; 95%CI1.24-1.79; EHR OR=1.51 [1.41-1.61]), having poor pre-pandemic mental health (LS OR=1.46 [1.17-1.83]; EHR OR=1.57 [1.47-1.68]) and poor general health (LS OR=1.62 [1.25-2.09]; EHR OR=1.26; [1.18-1.35]) were associated with higher risk of long COVID. Individuals with asthma (LS OR=1.32 [1.07-1.62]; EHR OR=1.56 [1.46-1.67]), and overweight or obesity (LS OR=1.25 [1.01-1.55]; EHR OR=1.31 [1.21-1.42]) also had higher risk. Non-white ethnic minority groups had lower risk (LS OR=0.32 [0.22-0.47]), a finding consistent in EHR. . Few participants had been hospitalised (0.8-5.2%). ConclusionLong COVID is associated with sociodemographic and pre-existing health factors. Further investigations into causality should inform strategies to address long COVID in the population.
cc_by
Texte intégral:
1
Collection:
09-preprints
Base de données:
PREPRINT-MEDRXIV
Type d'étude:
Cohort_studies
/
Experimental_studies
/
Observational_studies
/
Prognostic_studies
/
Rct
Langue:
En
Année:
2021
Type de document:
Preprint