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Variant-specific symptoms of COVID-19 among 1,542,510 people in England
Matthew Whitaker; Joshua Elliott; Barbara Bodinier; Wendy S Barclay; Helen Ward; Graham Cooke; Christl A Donnelly; Marc Chadeau-Hyam; Paul Elliott.
Affiliation
  • Matthew Whitaker; Imperial College London
  • Joshua Elliott; Imperial College London
  • Barbara Bodinier; Imperial College London
  • Wendy S Barclay; Imperial College London
  • Helen Ward; Imperial College London
  • Graham Cooke; Imperial College London
  • Christl A Donnelly; Imperial College London
  • Marc Chadeau-Hyam; Imperial College London
  • Paul Elliott; Imperial College London School of Public Health
Preprint de En | PREPRINT-MEDRXIV | ID: ppmedrxiv-22275368
ABSTRACT
Infection with SARS-CoV-2 virus is associated with a wide range of symptoms. The REal-time Assessment of Community Transmission -1 (REACT-1) study has been monitoring the spread and clinical manifestation of SARS-CoV-2 among random samples of the population in England from 1 May 2020 to 31 March 2022. We show changing symptom profiles associated with the different variants over that period, with lower reporting of loss of sense of smell and taste for Omicron compared to previous variants, and higher reporting of cold-like and influenza-like symptoms, controlling for vaccination status. Contrary to the perception that recent variants have become successively milder, Omicron BA.2 was associated with reporting more symptoms, with greater disruption to daily activities, than BA.1. With restrictions lifted and routine testing limited in many countries, monitoring the changing symptom profiles associated with SARS-CoV-2 infection and induced changes in daily activities will become increasingly important.
Licence
cc_by_nc_nd
Texte intégral: 1 Collection: 09-preprints Base de données: PREPRINT-MEDRXIV Type d'étude: Prognostic_studies / Rct Langue: En Année: 2022 Type de document: Preprint
Texte intégral: 1 Collection: 09-preprints Base de données: PREPRINT-MEDRXIV Type d'étude: Prognostic_studies / Rct Langue: En Année: 2022 Type de document: Preprint