Advances in live-imaging aging reporter mice / 生理学报
Acta Physiologica Sinica
; (6): 836-846, 2023.
Article
de Zh
| WPRIM
| ID: wpr-1007794
Bibliothèque responsable:
WPRO
ABSTRACT
Aging is an independent risk factor for chronic diseases in the elderly, and understanding aging mechanisms is one of the keys to achieve early prevention and effective intervention for the diseases. Aging process is dynamic and systemic, making it difficult for mechanistic study. With recent advances in aging biomarkers and development of live-imaging technologies, more and more reporter mouse models have been generated, which can live monitor the aging process, and help investigate aging mechanisms at systemic level and develop intervention strategies. This review summarizes recent advances in live-imaging aging reporter mouse models based on widely used aging biomarkers (p16Ink4a, p21Waf1/Cip1, p53 and Glb1), and discusses their applications in aging research.
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Vieillissement
/
Marqueurs biologiques
/
Protéine p53 suppresseur de tumeur
/
Inhibiteur p16 de kinase cycline-dépendante
/
Inhibiteur p21 de kinase cycline-dépendante
Limites:
Animals
/
Humans
Langue:
Zh
Journal:
Acta Physiologica Sinica
Année:
2023
Type de document:
Article