Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 100-103, 2002.
Article
de Zh
| WPRIM
| ID: wpr-245355
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether DRD4 exon III48 bp variant number tandem repeat(VNTR) polymorphism is associated with tic disorder.</p><p><b>METHODS</b>One hundred and twenty-two nucleus families were collected using Structured clinical interview for genetic study of Tourette syndrome and related disorders for family-based association analysis of tic disorder and DRD4 exon III 48bp VNTR polymorphism. One hundred and twenty-two trios were divided into two groups: tic disorder group (82 trios of Tourette syndrome or chronic tic disorder, TS&CT) and tic disorder accompanied with attention deficit and hyperactivity disorder (ADHD) group (40 trios of Tourette syndrome or chronic tic disorder accompanied with ADHD, TS&ADHD). Transmission disequilibrium test (TDT), in addition to polymerase chain reaction and VNTR technique were conducted in 122 trios.</p><p><b>RESULTS</b>There exist 5 alleles at this polymorphic locus in this sample including DRD4 exon III 48bp 2-6 repeats. No transmission disequilibrium was found between DRD4 exon III 48 bp VNTR and tic disorder (chi square=7.44, P 0.12); however, when the sample was divided into two groups, transmission disequilibrium was noticed between the cases of TS&ADHD and this locus by overall allele-wise analysis (chi square=11.74, P 0.02), and there exists transmission disequilibrium exclusively between 5 or 6 repeats of 48bp VNTR(longer alleles) by allele-wise analysis (chi square=10.57, P 0.032, chi square=6.13, P 0.01). No transmission disequilibrium was seen between TS&CT and DRD4 exon III 48bp VNTR(chi square=3.38, P 0.50).</p><p><b>CONCLUSION</b>The results of this study have revealed an association between the longer alleles of DRD4 exon III 48bp VNTR polymorphism and tic disorder accompanied with ADHD, thus suggesting a possible genetic risk factor of tic disorder accompanied with ADHD in Chinese.</p>
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Polymorphisme génétique
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Trouble déficitaire de l'attention avec hyperactivité
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Troubles des tics
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ADN
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Déséquilibre de liaison
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Exons
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Santé de la famille
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Récepteur D2 de la dopamine
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Répétitions minisatellites
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Allèles
Type d'étude:
Qualitative_research
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Risk_factors_studies
Limites:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Langue:
Zh
Journal:
Chinese Journal of Medical Genetics
Année:
2002
Type de document:
Article