Cystic degeneration in liver injury induced by CCl4 in SD rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1880-1881, 2006.
Article
de Zh
| WPRIM
| ID: wpr-246056
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the hepatic injury induced by CCl4in SD rat.</p><p><b>METHOD</b>40 SD rats were allocated to male and female group, consisting of 20 animals/sex/group. SD rats were given at 2 mL x kg(-1) of 10% CCl4 through celiac injection per 3 day for 12 days. All rats were killed by anaesthesia of ethyl ether and bleeding through abdominal aorta at 12th day. Liver tissue was fixed in 10% neutral formalin, embedded in paraffin, cut at a nominal thickness of 3 microm, stained with hematoxylin and eosin ( H&E) , evaluated at by microscopic examination.</p><p><b>RESULT</b>19 cases with local necrosis, 8 cases with fatty degeneration, 9 cases with cystic degeneration and 2 cases with fibrosis were seen in group male. 20 cases with local necrosis, 9 cases with fatty cases degeneration, 1 case with cystic degeneration and 1 case with fibrosis were seen in group female. The incidence of cystic degeneration in male group was found significantly higher than that in female group (P < 0. 05) , but the incidence of other lesions was no significant difference between male and female group.</p><p><b>CONCLUSION</b>CCl4 induces local necrosis , fatty degeneration, fibrosis and cystic degeneration in SD rat. The incidences of local necrosis , fatty degeneration and fibrosis were no significantly difference between male and female rat, but the incidence of cystic degeneration in male rats was significant higher than that in female rats.</p>
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Anatomopathologie
/
États précancéreux
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Tétrachloro-méthane
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Facteurs sexuels
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Rat Sprague-Dawley
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Kystes
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Modèles animaux de maladie humaine
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Lésions hépatiques dues aux substances
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Foie
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Cirrhose du foie
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
Zh
Journal:
China Journal of Chinese Materia Medica
Année:
2006
Type de document:
Article