Study of metabolic syndrome and insulin secretion function in first-degree relatives of type 2 diabetic patients in a large cohort study in Sichuan province of China / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1110-1114, 2010.
Article
de Zh
| WPRIM
| ID: wpr-260928
Bibliothèque responsable:
WPRO
ABSTRACT
This investigation was directed to the metabolic syndrome and the islet beta-cell secretory function in the first-degree relatives (FDR) of type 2 diabetic patients in Sichuan province. A large cohort study was designed. Totally 1929 subjects were investigated. They were in two groups: FDR group comprising 505 first-degree relatives of type 2 diabetic patients, and Control group comprising 1424 controls without positive family history of Diabetes. Blood pressure, weight, waist, plasma glucose, lipids and insulin were measured. HOMA-IR and HOMA-beta indexes were used to evaluate insulin resistance and beta-cell secretion function. The insulin sensitivity index (ISI) and glucose disposition index (DI) were also used to evaluate insulin resistance. After adjustment for age and sex, HOMA-IR increased, ISI, DI and HOMA-beta decreased in FDR group when compared with controls (P < 0.05). The incidence of co-existed three or more metabolic disorders and metabolic syndrome was higher in FDR group than that in control group (P < 0.05). In FDR group, HOMA-IR increased, HOMA-beta, DI and ISI decreased while the number of co-existing metabolic disorders increased. But when the number of co-existing metabolic disorders > or = 4, HOMA-IR increased no longer and ISI decreased no more. Metabolic disorders occurred more frequently in FDR of diabetic patients than those in individuals without positive family history. As the number of co-existing metabolic disorders increased, the beta-cell secretion function and insulin sensitivity became worse. Our study indicated that it is necessary to keep on monitoring the metabolic index in FDR of type 2 diabetes and provide early preventive interventions.
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Insulinorésistance
/
Chine
/
Épidémiologie
/
Enquêtes et questionnaires
/
Études de cohortes
/
Ilots pancréatiques
/
Syndrome métabolique X
/
Diabète de type 2
/
Génétique
/
Hyperglycémie provoquée
Type d'étude:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Pays/Région comme sujet:
Asia
Langue:
Zh
Journal:
Journal of Biomedical Engineering
Année:
2010
Type de document:
Article