Pulmonary thromboembolism in systemic lupus erythematosus: clinical analysis of 11 cases / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 329-331, 2002.
Article
de Zh
| WPRIM
| ID: wpr-278171
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the diagnosis and therapy of systemic lupus erythematosus (SLE) patients with pulmonary thromboembolism (PTE).</p><p><b>METHODS</b>11 hospitalized cases were reviewed retrospectively in PUMC Hospital during January 1984-July 2001.</p><p><b>RESULTS</b>All 11 cases were suffered from severe active lupus with PTE. The SLE-DAI (SLE-disease active index) was 21.9 +/- 4.9. 7 cases had first onset of progressive Raynaud phenomenon. Anti-RNP antibody was positive in 73% of the cases. Echocardiogram revealed medium-severe pulmonary hypertension. When PTE was found, while 6 cases had started with smaller to medium dose of prednisone treatment, which was 20-30 mg/d, and other 4 cases received no prednisone. Only 1 received large dose of prednisone and immunosuppressor. Large dosage of prednisone, immunosuppressor with or without anticoagulant were given to those 6 and 4 patients after final diagnosis, respectively. 6 of 7 cases showed relieved Raynaud phenomenon while 4 cases hemoptysis were disappeared, echocardiogram had confirmed that pulmonary artery pressure decreased in 4 cases. [(31.7 +/- 12.4) mmHg]. 5 cases survived, 3 were dead and 3 failed to be followed up.</p><p><b>CONCLUSIONS</b>Patients of SLE with PTE are liable to be misdiagnosed or missed-diagnosed, The risk factors are active-SLE, progressive Raynaud phenomenon, and symptoms of thromboembolism, positive anti-RNP antibody and mild-medium pulmonary artery hypertension. Combined therapy of present available measures like large dose of prednisone, immunosuppressors and anticoagulant are highly recommended.</p>
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Embolie pulmonaire
/
Thérapeutique
/
Études rétrospectives
/
Diagnostic
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Lupus érythémateux disséminé
Type d'étude:
Diagnostic_studies
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Observational_studies
/
Risk_factors_studies
Limites:
Adult
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Female
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Humans
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Male
Langue:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Année:
2002
Type de document:
Article