Alkaloids from Senecio scandens / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2572-2575, 2010.
Article
de Zh
| WPRIM
| ID: wpr-279398
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alkaloids from Senecio scandens.</p><p><b>METHOD</b>Compounds were isolated with silica gel and Sephadex LH-20 column chromatography and their structures were determined by spectral analysis and chemical evidence. The hepatic cytotoxicity of isolated compounds was tested by MTT method in vitro.</p><p><b>RESULT</b>Six alkaloids were obtained and identified as adonifoline (1), 7-angeloylturneforcidine (2), hordenine (3), 1, 3, 6, 6-tetramethyl-5, 6, 7, 8-tetrahydro-isoquinolin-8-one (4), 4-(pyrrolidin-2-one) -phenyl acetic acid (5), (4-pyrrolidinophenyl) acetic acid (6).</p><p><b>CONCLUSION</b>Compound 6 is a new natural product, compounds 3, 4 were obtained from the genus Senecio for the first time, compounds 2, 5 were obtained from this plant for the first time. Compound 1 showed significant growth inhibitory effect against hepatocyte at 100 micromol x L(-1).</p>
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Pharmacologie
/
Alcaloïdes de type pyrrolizidine
/
Senecio
/
Tyramine
/
Cellules cultivées
/
Chimie
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Chromatographie en phase liquide à haute performance
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Dextrane
/
Acide acétique
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Hépatocytes
Limites:
Animals
Langue:
Zh
Journal:
China Journal of Chinese Materia Medica
Année:
2010
Type de document:
Article