Effects of total flavonoids of Chrysanthemum indicum on free radical in adjuvant arthritic rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 344-347, 2010.
Article
de Zh
| WPRIM
| ID: wpr-281021
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of total flavonoids of Chrysanthemum indicum (TFC) on metabolism of free radical and immunoregulatory effects in adjuvant arthritis (AA) rats.</p><p><b>METHOD</b>AA rats were induced by Freunds complete adjuvant. Secondary paw swelling of AA rats was measured with volume meter to observe the antirheumatic effect of TFC. The levels of SOD, MDA and NO in serum and supernatant of peritoneal macrophage were measured by commercial assay kits. ConA-induced splenocyte proliferation and IL-2 level produced by splenocyte were detected by MTT method.</p><p><b>RESULT</b>TFC could decrease the levels of MDA and NO, as well as increase the activity of SOD in serum and supernatant of peritoneal macrophage compared with AA model group. Meanwhile, the suppressed lymphocyte proliferation and IL-2 production of splenic lymphocytes in AA rats were reversed by treatment with TFC.</p><p><b>CONCLUSION</b>TFC showed significant therapeutical effect on adjuvant arthritis and its mechanism was at least in part related to the antioxidant and immunoregulatory effects.</p>
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Arthrite expérimentale
/
Rate
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Superoxide dismutase
/
Flavonoïdes
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Activation des lymphocytes
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Cellules cultivées
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Chimie
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Interleukine-2
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Rat Sprague-Dawley
/
Biologie cellulaire
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
Zh
Journal:
China Journal of Chinese Materia Medica
Année:
2010
Type de document:
Article