Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 460-464, 2017.
Article
de En
| WPRIM
| ID: wpr-311391
Bibliothèque responsable:
WPRO
ABSTRACT
Laboratory-based pathogen isolation, identification, and toxicity determination were performed on samples from a suspected case of infant botulism. Mice injected with cultures generated from the enema sample and ingested Powered infant formula (PIF) presented typical signs of botulism. Antitoxins to polyvalent botulinum neurotoxins (BoNTs) and monovalent BoNT type B antitoxin had protective effects. Clostridium botulinum isolated from the enema and residual PIF samples were positive for type B toxin. Pulsed-field gel electrophoresis (PFGE) revealed that the two strains of C. botulinum isolated from the two samples produced indistinguishable pulsotypes. These findings confirmed this case of type B infant botulism associated with the ingestion of PIF contaminated by type B C. botulinum spores.
Mots clés
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Toxines botuliniques
/
Botulisme
/
Épidémiologie
/
Clostridium botulinum
/
Tests de toxicité
/
Tube digestif
/
Diagnostic
/
Toxicité
/
Pékin
/
Microbiologie
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites:
Animals
/
Humans
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Biomedical and Environmental Sciences
Année:
2017
Type de document:
Article