Expression of OCTN2 mRNA in the human epididymis and its significance / 中华男科学杂志
National Journal of Andrology
; (12): 242-244, 2008.
Article
de Zh
| WPRIM
| ID: wpr-319236
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of L-Carnitine transport and the expression of OCTN2 mRNA in the human epididymis so as to provide a theoretical basis for male contraception.</p><p><b>METHODS</b>We collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR.</p><p><b>RESULTS</b>OCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis.</p><p><b>CONCLUSION</b>The human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation. With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.</p>
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
ARN messager
/
Régulation de l'expression des gènes
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Contraception
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RT-PCR
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Analyse de profil d'expression de gènes
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Transporteurs de cations organiques
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Épididyme
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Membre-5 de la famille-22 de transporteurs de solutés
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Génétique
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Métabolisme
Limites:
Humans
/
Male
Langue:
Zh
Journal:
National Journal of Andrology
Année:
2008
Type de document:
Article