Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression / 南方医科大学学报
Journal of Southern Medical University
; (12): 2442-2445, 2009.
Article
de Zh
| WPRIM
| ID: wpr-325095
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the presence of abnormal metabolism in the thalamus and hypothalamus in patients with first-episode depression.</p><p><b>METHODS</b>Thirty drug-naive patients with first-episode depression and 30 age-matched controls were scanned with proton magnetic resonance spectroscopy ((1)H-MRS) for Naa, Cho, Cr and mI.</p><p><b>RESULTS</b>Compared with the control group, the patients showed significantly reduced mI and mI/Cr of the hypothalamus, reduced mI/Cr of the left thalamus, and lowered Cho, ml, and ml/Cr of the right thalamus (P<0.05).</p><p><b>CONCLUSION</b>Patients with first-episode depression may have myo-inositol and phosphoric acid metabolism disorder in the thalamus and hypothalamus with malfunction of cellular osmotic pressure adjustment mechanism. Abnormal mI/Cr in the thalamus and hypothalamus may represent an important biochemical change in advanced patients with depression.</p>
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Protons
/
Thalamus
/
Spectroscopie par résonance magnétique
/
Études cas-témoins
/
Choline
/
Créatine
/
Dépression
/
Diagnostic
/
Hypothalamus
/
Inositol
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limites:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Langue:
Zh
Journal:
Journal of Southern Medical University
Année:
2009
Type de document:
Article