Influence of anisodamine chronic administration on the vascular function and morphology spontaneously hypertensive rats / 国际外科学杂志
International Journal of Surgery
; (12): 510-512, 2008.
Article
de Zh
| WPRIM
| ID: wpr-399045
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To investigate the influence of Anisodamine chronic administration on the vascular function and morphology of SHR. Methods The SHR were injected by chronic abdominal Anisodamine; Then the SHR were sacrificed after ten weeks. The abdominal aorta were obtained after perfusion and the changes of aorta morphology were observed under a microscope. The influence of Anisedamine on the vasculovr funtion was investigated by the rat's aorta rings perfusion. Results In the physiological state, given SHR long-term Anisodamine, the vascular endothelial and smooth muscle relaxation will significantly improve; Anisodamine chronic adminstration can inhibit the formation of aortic aneurysm and change a benign vascular structure. Conclusion Anisodamine chronic adminstration will improve the vascular endothelial and smooth muscle relaxation, and change a benign vascular structure, Anisodamine has a protective effect on endothelial and smooth muscle.
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
International Journal of Surgery
Année:
2008
Type de document:
Article