Cucurmosin induced the apoptosis of pancreatic cancer cell SW1990 via EGFR signaling pathway / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 700-703, 2012.
Article
de Zh
| WPRIM
| ID: wpr-419303
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To investigate the mechanisms involved in cucurmosin-induced apoptosis of pancreatic cancer cell SW1990.Methods The expression of EGFR,PI3K,Akt,Bad,Caspase -9,mTOR,P70S6K-α,and 4E BP1 at the protein level were detected by western blot analysis,and RTPCR was used to determine EGFR mRNA expression.Results An increased concentration of cucurmosin showed a subsequent decrease in the expression of EGFR,PI3K,Akt,mTOR,P70S6Kα,and 4E -BP1,whereasthe expression of Bad and Caspase-9 were elevated.However,the mRNA expression of EGFR was unchanged.Conclusion Cucurmosin is shown to induce the apoptosis of pancreatic cancer cell SW1990 by down regulating the expression of EGFR and thus inactivating the PI3K/Akt/mTOR signaling pathway.
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
Chinese Journal of Hepatobiliary Surgery
Année:
2012
Type de document:
Article