Outlook and advances in research on miRNAs in cancer / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
; (6): 429-434, 2015.
Article
de Zh
| WPRIM
| ID: wpr-467212
Bibliothèque responsable:
WPRO
ABSTRACT
microRNA (miRNA)is a kind of non-protein-coding small RNA that is different from mRNA. miRNAs interact with the 3’ untranslated region (3’UTR )of the target mRNA,resulting in either complete degradation or translational inhibition of the target mRNA.miRNAs play a vital role in tumorigenesis,growth, migration and invasion.The regulation of miRNA is closely related to its function in cancer.Competing endogenous RNA (ceRNA),circular RNA (circRNA)and RNA binding protein (RBP)as regulatory molecules are involved in the expression regulation of target genes.It may be one reason why the miRNA has complicated and diversified functions in diverse cancer tissues or cancer cells.The future direction of miRNA research is to study the latest technology to find the network control mechanism of miRNA in the specific cells.
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
Journal of Xi'an Jiaotong University(Medical Sciences)
Année:
2015
Type de document:
Article