Stability Study of Tramadol,Fentanyl and Ondansetron Combined with 0.9% Sodium Chloride Injection in Analgesia Pump / 中国药房
China Pharmacy
; (12): 1048-1050, 2016.
Article
de Zh
| WPRIM
| ID: wpr-501356
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE:To study the stability of Tramadol hydrochloride,Fentanyl citrate and Ondansetron hydrochloride in-jection in 0.9% Sodium chloride injection. METHODS:At room temperature [(25±1)℃],three injections were poured into infu-sion bag of disposable analgesia pump,and diluted with 0.9% Sodium chloride injection. The changes in precipitation,turbidity, color and pH value of the mixture were observed. The relative percentage of three injections within 72 h were determined by HPLC method. RESULTS:There was no significant change in the pH value and appearance of the mixture. Relative percentage of tramad-ol hydrochloride,fentanyl citrate and ondansetron hydrochloride were all higher than 97% within 72 h. CONCLUSIONS:The mix-ture of Tramadol hydrochloride,Fentanyl citrate and Ondansetron hydrochloride injection in 0.9% Sodium chloride injection keep stable within 72 h under room temperature.
Texte intégral:
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Base de données:
WPRIM
Langue:
Zh
Journal:
China Pharmacy
Année:
2016
Type de document:
Article