MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2
Experimental & Molecular Medicine
; : e112-2014.
Article
de En
| WPRIM
| ID: wpr-50915
Bibliothèque responsable:
WPRO
ABSTRACT
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Régulation de l'expression des gènes tumoraux
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Mouvement cellulaire
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Facteur de croissance fibroblastique de type 2
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Carcinome pulmonaire non à petites cellules
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MicroARN
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Prolifération cellulaire
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Poumon
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Tumeurs du poumon
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Invasion tumorale
Limites:
Female
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Humans
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Male
Langue:
En
Journal:
Experimental & Molecular Medicine
Année:
2014
Type de document:
Article