Study of CJ016 in treatment of lung cancer / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 384-388, 2017.
Article
de Zh
| WPRIM
| ID: wpr-510705
Bibliothèque responsable:
WPRO
ABSTRACT
Aim Tostudythetherapeuticeffectof CJ016 on human lung cancer model and the mecha-nism.Methods Anexperimentalhumanlungadeno-carcinoma model of A549 was set up to investigate the anti-tumor effect of CJ016,while the effect of angio-genesis and apoptosis in tumor were detected.Results In vitro,the cell proliferation was inhibited signifi-cantly by CJ016,and the value of IC50 was 34. 22 nmol ·L-1 .In vivo,the tumor inhibition rate and T/C%value were 70. 08%and 27. 75%,respectively,at the dose of 20 mg·kg-1 .Meanwhile,CJ016 could reduce the expression of CD31 and promote the apoptosis of tumorcells.Conclusion CJ016caninhibitthegrowth of A549 cells,and the possible mechanism may be re-lated to the reduction of angiogenesis and inducing tumor cell apoptosis.
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1
Base de données:
WPRIM
Langue:
Zh
Journal:
Chinese Pharmacological Bulletin
Année:
2017
Type de document:
Article