The Study of Nimodipine in Treating Pregnancy Induced Hypertension and its Effect on Intraplatelet Free Calcium / 中华围产医学杂志

ABSTRACT

Objective To evaluate the effects of nimodipine (NIM) on pregnancy induced hypertension(PIH) and to assesse the effects of nimodipine on intraplatelet free calcium(PF[Ca 2+ ] i). Methods Fourty eight patients with moderate or severe PIH were randomized to receive either NIM or magnesium sulfate. We observed the change of blood pressure, urc protein, PF[Ca 2+ ] i and symptoms of preeclampsia before and after medication. We compared the pregnancy outcome of the two groups. Results 1.There was significant reduction of blood pressure at 1/2 h?1 h and 2 h after the administration of nimodipine. The maternal heart rate increased significantly ( P