The Percutaneous Permeability of Methoxypsoralen Liposomal Gel / 中国药房
China Pharmacy
; (12)2001.
Article
de Zh
| WPRIM
| ID: wpr-521624
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE:To study the percutaneous permeability of methoxypsoralen liposomal gel METHODS:The preparations were applied on the rat skin in vitro and in vivo with common gel and Mingbailing tincture as control,and the drug concentrations in the receiver,skin,blood and other organs were determined by RP-HPLC RESULTS:In vitro experiment,liposomal gel showed the lowest percutaneous permeation rate and the highest retention in skin In vivo studies illuminated that the skin depositions of drug encapsulated in liposome was(4 37?0 91) and (3 36?0 58) times those of the common gel and tincture respectively CONCLUSION:Methoxypsoralen liposomal gel showed an evident targeting effect on skin
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
China Pharmacy
Année:
2001
Type de document:
Article