Effects of nanoscale titanium dioxide on intercellular gap junction communication in human lung fibroblasts / 北京大学学报(医学版)
Article
de Zh
| WPRIM
| ID: wpr-565826
Bibliothèque responsable:
WPRO
ABSTRACT
Objective:To investigate the effects of nanoscale titanium dioxide(Nano-TiO2) on gap junctional intercellular communication(GJIC) between human lung fibroblasts.Methods: Human lung fibroblasts were exposed to two different sizes Nano-TiO2(25 nm and 80 nm) for 24 hours at the concentrations of 0,10,20,40 and 80 mg/L,respectively.The GJIC between cells was measured by using fluorescence redistribution after photobleaching(FRAP) assay.Results: The results showed that GJIC between cells was significantly inhibited both by 25 nm and 80 nm Nano-TiO2 in a dose-dependent manner.The fluorescence recovery rate was 20.81%?1.93% in control group,7.26%?0.91%(P
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
Journal of Peking University(Health Sciences)
Année:
2004
Type de document:
Article