Effects of Interleukin-1 Receptor Antagonist Gene Polymorphism in Cardiovascular Events of Patients with Coronary Arterial Disease / 航天医学与医学工程

ABSTRACT

Objective To test the relationship between interleukin-1 receptor antagonist(IL-1Ra)gene polymorphisms and the incidence of coronary artery disease and the effect of IL-1Ra gene polymorphisms in prediction cardiovascular events.Methods Polymerase chain reaction was used in a series of 220 patients of coronary arterial disease(CAD)and a control group of 100 cases.A prospective 12 months follow-up was conducted in the CAD patients and cardiovascular events were recorded.Serum levels of total cholesterol,triglyceride,low density lipoprotein cholesterol,fibrinogen,hsCRP,and body mass index were measured.Results There was no significant difference between CAD patients and the control subjects in IL-1Ra gene polymorphisms.However,the IL-1Ra gene polymorphism was significantly higher among subjects in CAD patients without cardiovascular events than those with cardiovascular events.Conclusion It suggests that IL-1Ra gene polymorphisms can not predict the incident of coronary heart disease but might possess some protection for the patients of coronary arterial disease from cardiovascular events.