BRAF-V600E mutation in pediatric patients with Langerhans cell histiocytosis and ts clinical features / 实用医学杂志
The Journal of Practical Medicine
; (24): 3391-3394, 2017.
Article
de Zh
| WPRIM
| ID: wpr-658475
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To investigate the BRAF-V600E mutation in pediatric patients with Langerhans cell histiocytosis and its clinical features. Methods A retrospective study was conducted among 27 children who were diagnosed in our hospital between August 2009 and June 2015 ,including 17 males and 10 females. BRAF-V600E was amplified from tissue samples of the 27 children with LCH by PCR and the relationship was analysed between the mutation and clinical features ,outcome. Results BRAF-V600E mutation was found in 9 cases within all 27 tested cases(33.3%). Significant difference was not found in age ,gender ,system involvement ,6-week reaction ,3-year overall survival and event-free survival between BRAF-V600E positive and negative groups. Conclusions BRAF-V600E mutation was found in Chinese pediatric LCH patients with positive rate of 33.3%, that indicates LCH might be a neoplastic disease. However ,its definite role on disease onset ,system involvement and disease progression remains unknown.
Texte intégral:
1
Base de données:
WPRIM
Type d'étude:
Observational_studies
Langue:
Zh
Journal:
The Journal of Practical Medicine
Année:
2017
Type de document:
Article