Medication Persistence for Osteoporosis and Its Related Factor in Patients with Osteoporotic Compression Vertebral Fracture / 대한골다공증학회지

ABSTRACT

INTRODUCTION: Osteoporotic vertebral fractures, which account for the largest part of the disease has become important and common diseases. We studied persistence for osteoporosis medication and its related factor in patients with osteoporotic compression vertebral fracture. METHODS: A total of 458 patients that visited our outpatient clinic with osteoporotic vertebral fractures and were prescribed with osteoporosis medication at the Seoul Spine Center from January 2010 to February 2014 and were analyzed retrospectively. The male to female ratio was 403: 55 and the mean age was 75 years. Survival analysis was used with the Kaplan-Meier method. Related factor analysis was performed with the log rank test and Cox regression test. RESULTS: The survival rate at 6 months was 52%, 12 months was 40%, 24 months was 28%, and at 3 years it was 25%. There was no difference between the persistent rate according to age. Women demonstrated higher persistent rate than men in significantly. It showed a significant difference between some of the groups in accordance with the dose rate and duration of the drug dose interval. Especially, medication change group had significant higher persistence rate than not changing group. CONCLUSIONS: Persistence rate of osteoporosis drugs, decreased rapidly with the passage of time. The patients with changing medication during follow-up had significantly higher persistence ratio than those without it. The persistence rate of osteoporosis medication could be increased through actively solving the problems of the patients, which are associated with taking medication.