Stability of tramadol hydrochloride with fentanyl citrate in 0 .9%sodium chloride injection / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 348-351, 2014.
Article
de Zh
| WPRIM
| ID: wpr-790357
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9%sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9%sodium chloride injection within 72 hours at ambient temperature were observed .The concentrations of the two drugs were determined by HPLC .The chromatographic separation was achieved on SinoChrom ODS-BP column, and the mobile phase consisted of acetonitrile:0.05 mol/L potassium dihydrogen phosphate (25:75) at a flow rate of 1.0 ml/min..Results No significant differences were found in the pH value and appearance of the solution . The contents of tramadol hydrochloride and fentanyl citrate were high than 98%within 72 hours.Conclusion The mixture of tramadol hydrochloride with fentanyl citrate in 0.9%sodium chloride injection was stability within 72 hours under room temperature .
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
Journal of Pharmaceutical Practice
Année:
2014
Type de document:
Article