The clinical observation of serum specific biomarkers in patients with chronic graft-versus-host disease / 中华血液学杂志
Chinese Journal of Hematology
; (12): 948-952, 2019.
Article
de Zh
| WPRIM
| ID: wpr-801371
Bibliothèque responsable:
WPRO
ABSTRACT
Objective@#Chronic graft-versus-host disease (cGVHD) is a major long-term complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . It is important to study the changes of serum biomarkers expression in patients for early diagnosis and treatment.@*Methods@#The expression levels of five serum protein markers (IL-1b, IL-16, CXCL9, CCL19, CCL17) in patients with or without cGVHD after allo-HSCT were detected by liquid suspension microarray.@*Results@#Compared with the control group without cGVHD, the expression levels of CXCL9 and CCL17 in serum of patients with cGVHD were significantly increased (P<0.05) . CCL17 was correlated with the severity of cGVHD (P<0.001) . CXCL9 was significantly increased in the serum of patients with skin lesion (P<0.01) , and CCL17 was significantly expressed in cGVHD patients with liver as the target organ (P<0.01) .@*Conclusion@#The combination of CXCL9 and CCL17 can be used as serum biomarkers of cGVHD, which has certain reference value in assisting the diagnosis and evaluation of cGVHD severity.
Texte intégral:
1
Base de données:
WPRIM
Type d'étude:
Screening_studies
Langue:
Zh
Journal:
Chinese Journal of Hematology
Année:
2019
Type de document:
Article