Application of isothermal titration calorimetry in drug research / 中草药
Chinese Traditional and Herbal Drugs
; (24): 5463-5467, 2018.
Article
de Zh
| WPRIM
| ID: wpr-851568
Bibliothèque responsable:
WPRO
ABSTRACT
Isothermal titration calorimetry (ITC) is a real-time, quantitative, on-line, and dynamic thermal analysis technique for describing reaction processes. Some thermodynamic parameters, such as association constant, dissociation constant, stoichiometry ratio, enthalpy change, and entropy change of host and guest interaction, can be obtained in ITC analysis. This technique has the advantages of high calorimetric sensitivity and accurate measurement. In this paper, the principle and application characteristics of ITC technology are described, and the application of this technique in drug research are reviewed, including the interaction between drugs and proteins, the interaction between drugs and DNA molecules, clinical drug compatibility, the application in pharmaceutical preparations and the interaction between drugs and biomembrane. Lastly, the application of this technique in the nonspecific molecular interaction is prospected.
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
Chinese Traditional and Herbal Drugs
Année:
2018
Type de document:
Article