Pharmacodynamic effects of main chemical components of Lindera aggregata based on network pharmacology / 中草药

ABSTRACT

Objective To predict the pharmacological effect and targets of main chemical components of Lindera aggregata, and construct the multi-target network. Methods The potential targets and pathways of linderene acetate, isocembrol, laurolitsine, β-humulene, chamazulene, laurotetanine, and lindestrenolide, selected as the representative compounds of oils, alkaloids, and furan sesquiterpene lactones from Linderae Radix, were predicted by methods of network pharmacology. The pharmacodynamic effects of main chemical constituents of L. aggregata was analyzed by data integration. Results The in silico prediction results showed that seven compounds of L. aggregata affected 20 related pathways through 40 potential targets. The pathways were involved in several links including inflammatory, analgesic, gastrointestinal movement regulation, anti-oxidation, antitumor, liver injury protection, and immunoregulation. The various components showed common targets, pathways, and pharmacodynamic effects and had different emphases. Conclusion The pathways related to L. aggregata oils, alkaloids, and furan sesquiterpene lactones were connected by the common targets, showing the synergistic effect of different compounds by acting on multi-targets and multi-pathways. This study provides references for systematic exploration on the pharmacological actions and mechanisms of L. aggregata.