Research Advance of Autophagy in Acute Intestinal Graft-Versus-Host Disease--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 998-1001, 2021.
Article
de Zh
| WPRIM
| ID: wpr-880182
Bibliothèque responsable:
WPRO
ABSTRACT
Acute intestinal graft-versus-host disease is a refractory disease which can affect implantation and become a threat to life in severe cases. Autophagy is an intracellular degradation pathway necessary for maintaining cellular energy homeostasis. In recent years, a large number of studies have found that it is closely related to the pathogenesis and process of acute intestinal graft-versus-host disease. The main mechanisms may involve that inflammatory factor storm after pretreatment and infusion of donor cells induces disordered intestinal immune tolerance, and abnormal oxidative stress damages intestinal mucosal barrier, leading to intestinal rejection of acute graft-versus-host disease via mTOR signal pathway of autophagy, disordered mitophagy and other related pathways.
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Autophagie
/
Transduction du signal
/
Stress oxydatif
/
Maladie du greffon contre l'hôte
/
Tolérance immunitaire
Limites:
Humans
Langue:
Zh
Journal:
Journal of Experimental Hematology
Année:
2021
Type de document:
Article