Research progress in influences of epigenetic modifications on PD-L1 expression in tumors / 国际肿瘤学杂志
Journal of International Oncology
; (12): 345-348, 2022.
Article
de Zh
| WPRIM
| ID: wpr-954287
Bibliothèque responsable:
WPRO
ABSTRACT
Tumor cells expression of programmed death ligand-1 (PD-L1) is a major mechanism of immune escape and a predictor of therapeutic efficacy of immune checkpoint inhibitors. The expression of PD-L1 is regulated by a variety of mechanisms, among which epigenetic modifications such as DNA methylation, histone modification and non-coding RNA can promote the occurrence, development and drug resistance of tumors by regulating the expression of PD-L1. To clarify its regulation mechanism can bring new ideas for clinical immunotherapy of tumors.
Texte intégral:
1
Base de données:
WPRIM
Langue:
Zh
Journal:
Journal of International Oncology
Année:
2022
Type de document:
Article