Research Progress of Carboxymethyl Chitosan-Based Haemostatic Materials and Their Haemostatic Mechanism --Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 911-915, 2023.
Article
de Zh
| WPRIM
| ID: wpr-982150
Bibliothèque responsable:
WPRO
ABSTRACT
Effective haemostatic materials can quickly control bleeding and achieve the purpose of saving patients' lives. In recent years, chitosan-based haemostatic materials have shown good haemostatic effects, but their application is limited because chitosan is almost insoluble in water. Carboxymethyl chitosan-based haemostatic materials can promote hemostasis by activating red blood cells and aggregating platelets. In addition, carboxymethyl chitosan can bind with Ca2+ to activate platelets and coagulation factors, and start endogenous coagulation pathways, which can adsorb fibrinogen in plasma to promote haemostasis. In this paper, the latest research progress of carboxymethyl chitosan-based haemostatic materials and their haemostatic mechanism were reviewed, in order to further strengthen the understanding of the haemostatic mechanism of carboxymethyl chitosan-based haemostatic materials, and provide new idea for the research and clinical application of carboxymethyl chitosan-based haemostatic materials.
Mots clés
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Coagulation sanguine
/
Hémostatiques
/
Chitosane
/
Hémorragie
/
Hémostase
Limites:
Humans
Langue:
Zh
Journal:
Journal of Experimental Hematology
Année:
2023
Type de document:
Article