Diagnostic Significance of BAT in Anaphylaxis to Non-ionic Contrast Media / 法医学杂志
Journal of Forensic Medicine
; (6): 188-190, 2015.
Article
de Zh
| WPRIM
| ID: wpr-983985
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the diagnostic significance of basophil activation test (BAT) in anaphylaxis to non-ionic contrast media through testing the content of CD63, mast cell-carboxypeptidase A3 (MC-CPA3), and terminal complement complex SC5b-9 of the individuals by testing their levels in the normal immune group and the anaphylaxis groups to β-lactam drugs and non -ionic contrast media.@*METHODS@#The CD63 expression of basophilic granulocyte in blood was detected by flow cytometry. The levels of MC-CPA3 in blood serum and SC5b-9 in blood plasma were detected by ELISA.@*RESULTS@#The CD63 expression of basophilic granulocyte in blood, the levels of MC-CPA3 and SC5b-9 of anaphylaxis to non-ionic contrast media and β-lactam drugs were significantly higher than that in normal immune group (P < 0.05).@*CONCLUSION@#There is activation of basophilic granulocytes, mast cells and complement system in anaphylaxis to non-ionic contrast media. BAT can be used to diagnose the anaphylaxis to non-ionic contrast media.
Texte intégral:
1
Base de données:
WPRIM
Sujet principal:
Granulocytes basophiles
/
Complexe d'attaque membranaire du complément
/
Produits de contraste
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Carboxypeptidases A
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Antigène CD63
/
Cytométrie en flux
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Granulocytes
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Anaphylaxie
/
Mastocytes
Limites:
Humans
Langue:
Zh
Journal:
Journal of Forensic Medicine
Année:
2015
Type de document:
Article