Research progress in tumor microenvironment and therapeutic strategies of head and neck squamous cell carcinoma / 国际生物医学工程杂志

ABSTRACT

Head and neck squamous cell carcinoma of the head and neck is a very aggressive cancer with a poor prognosis in the late stages. Studies have revealed that head and neck squamous cell carcinoma is highly heterogeneous and immunosuppressive. The tumor microenvironment plays a key role in the development of head and neck squamous cell carcinoma, facilitating its evolution and resistance to treatment, thus adversely affecting patient prognosis. A comprehensive understanding of the tumor microenvironment could lead to new therapeutic interventions for head and neck squamous cell carcinoma. In this review, recent research findings on the tumor microenvironment and therapeutic strategies targeting the tumor microenvironment were reviewed, leading to the development of novel combination therapies to address head and neck squamous cell carcinoma and the tumor microenvironment, with the aim of gaining a deeper understanding of the disease and developing more accurate treatment plans for head and neck squamous cell carcinoma.