Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
Mem. Inst. Oswaldo Cruz
; 115: e200082, 2020. tab, graf
Article
in En
| LILACS, SES-SP
| ID: biblio-1135226
Responsible library:
BR1.1
ABSTRACT
Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
/
SES-SP
Main subject:
Respiratory Insufficiency
/
HIV Infections
/
HIV
/
Reactive Oxygen Species
/
Cell-Derived Microparticles
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2020
Document type:
Article
Affiliation country: