New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic effect on human tumor cell lines
Rev. bras. farmacogn
; 28(3): 333-338, May-June 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-958864
Responsible library:
BR1.1
ABSTRACT
ABSTRACT The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1",2"-epoxy-3"-hydroxy-3"-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2',6'-dimethoxy-4',5'-(2",2"-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and its glucoside, p-cumaric acid and cinnamic acid. The structures of all compounds were established on the basis of spectroscopic methods, mainly 1D and 2D NMR and HRESIMS, involving comparison with literature data. Cytotoxicity of compounds 1-4 was evaluated against AGP-01 (cancerous ascitic fluid), HCT-116 (colon adenocarcinoma), HL-60 (leukemia), PC-3 (prostate carcinoma), SF-295 (glioblastoma) and SKMEL 28 (melanoma) cell lines.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Language:
En
Journal:
Rev. bras. farmacogn
Journal subject:
FARMACIA
Year:
2018
Document type:
Article
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