Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications
Braz. j. med. biol. res
; 41(5): 344-350, May 2008. ilus
Article
in En
| LILACS
| ID: lil-484442
Responsible library:
BR1.1
ABSTRACT
T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous disease with respect to phenotype, gene expression profile and activation of particular intracellular signaling pathways. Despite very significant improvements, current therapeutic regimens still fail to cure a portion of the patients and frequently implicate the use of aggressive protocols with long-term side effects. In this review, we focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-ß, may contribute to T-ALL. Identifying the alterations that affect intracellular pathways that regulate cell cycle and apoptosis is essential to understanding the biology of this malignancy, to define more effective markers for the correct stratification of patients into appropriate therapeutic regimens and to identify novel targets for the development of specific, less detrimental therapies for T-ALL.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Phosphotransferases
/
T-Lymphocytes
/
Leukemia-Lymphoma, Adult T-Cell
/
Signal Transduction
/
Cell Differentiation
Type of study:
Etiology_studies
/
Guideline
/
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2008
Document type:
Article
/
Project document
Affiliation country: