The role of necroptosis in neurosurgical diseases
Braz. j. med. biol. res
; 48(4): 292-298, 4/2015.
Article
in En
| LILACS
| ID: lil-744365
Responsible library:
BR1.1
ABSTRACT
Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Brain Injuries
/
Cerebrovascular Disorders
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Apoptosis
/
Receptors, Death Domain
/
Necrosis
Limits:
Humans
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2015
Document type:
Article
/
Project document
Affiliation country: