Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.
Int Immunol
; 12(1): 113-7, 2000 Jan.
Article
in En
| MEDLINE
| ID: mdl-10607756
ABSTRACT
MyD88 is an adaptor molecule essential for signaling via the Toll-like receptor (TLR)/IL-1 receptor family. TLR4 is a member of the TLR family and a point mutation in the Tlr4 gene causes hyporesponsiveness to lipopolysaccharide (LPS) in C3H/HeJ mice. We have previously shown that both TLR4- and MyD88-deficient mice are hyporesponsive to LPS. In this study we examined the responsiveness of these two knockout mice to various bacterial cell wall components. Cells from TLR4-deficient mice responded to several kinds of LPS, peptidoglycan and crude cell wall preparation from Gram-positive bacteria and mycobacterial lysates. In contrast, macrophages and splenocytes from MyD88-deficient mice did not respond to any of the bacterial components we tested. These results show that MyD88 is essential for the cellular response to bacterial cell wall components.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Glycoproteins
/
Peptidoglycan
/
Receptors, Immunologic
/
Antigens, Differentiation
/
Cell Wall
/
Lipopolysaccharides
/
Receptors, Cell Surface
/
Drosophila Proteins
Limits:
Animals
Language:
En
Journal:
Int Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2000
Document type:
Article
Affiliation country: