[Topological similarity of antagonist binding sites in biogenic amine receptors]. / Topologicheskoe podobie uchastkov sviazyvaniia antagonistov v retseptorakh biogennykh aminov.
Ukr Biokhim Zh (1999)
; 71(3): 73-7, 1999.
Article
in Ru
| MEDLINE
| ID: mdl-10609327
ABSTRACT
The influence of physical and chemical properties of some sites of transmembrane receptor domains on the receptors ability to interact with nonspecific antagonists was investigated mathematically. The properties of sites located in 3rd and 7th transmembrane domains are most likely to explain pharmacological characteristics of the receptors. The possibility of receptor blocking by nonspecific antagonists not by competing with agonists but by influencing the receptor conformation is discussed.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Biogenic Amine
Limits:
Animals
/
Humans
Language:
Ru
Journal:
Ukr Biokhim Zh (1999)
Year:
1999
Document type:
Article
Affiliation country: