Loss of atheroprotective effect of estradiol in immunodeficient mice.
Endocrinology
; 141(1): 462-5, 2000 Jan.
Article
in En
| MEDLINE
| ID: mdl-10614672
ABSTRACT
Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apolipoproteins E
/
Arteriosclerosis
/
Estradiol
Limits:
Animals
Language:
En
Journal:
Endocrinology
Year:
2000
Document type:
Article
Affiliation country: