Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2.
J Immunol
; 165(8): 4552-60, 2000 Oct 15.
Article
in En
| MEDLINE
| ID: mdl-11035096
ABSTRACT
IL-2Ralpha-deficient (IL-2Ralpha(-/-)) mice exhibit an impaired activation-induced cell death for T cells and develop abnormal T cell activation with age. In our study, we found that IL-2Ralpha(-/-) mice at the age of 5 wk contained an increased number of CD44(+)CD69(-)CD8(+) T cells in lymph nodes, which expressed a high intensity of IL-2Rbeta and vigorously proliferated in response to a high dose of IL-15 or IL-2. The T cells produced a large amount of IFN-gamma in response to IL-15 plus IL-12 in a TCR-independent bystander manner. When IL-2Ralpha(-/-) mice were inoculated i.p. with HSV type 2 (HSV-2) 186 strain, they showed resistance to the infection accompanied by an increased level of serum IL-15. The depletion of CD8(+) T cells by in vivo administration of anti-CD8 mAb rendered IL-2Ralpha(-/-) mice susceptible to HSV-2-induced lethality. These results suggest that memory-type CD8(+) T cells play a novel role in the protection against HSV-2 infection in IL-2Ralpha(-/-) mice.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Interleukin-2
/
Herpes Genitalis
/
T-Lymphocyte Subsets
/
CD8-Positive T-Lymphocytes
/
Immunologic Memory
Limits:
Animals
Language:
En
Journal:
J Immunol
Year:
2000
Document type:
Article
Affiliation country: