Differential expression of the cell-adhesion molecule Nr-CAM in hyperplastic and neoplastic human pancreatic tissue.
Hum Pathol
; 32(4): 396-400, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11331956
ABSTRACT
Nr-CAM is a member of the immunoglobulin superfamily of neural cell-adhesion molecules initially thought to be expressed mainly in the brain. Here we show the presence of Nr-CAM protein in normal human pancreas and characterize its expression in hyperplastic and neoplastic human pancreatic tissue. Nr-CAM is expressed on the cell surface in normal pancreatic acini with enhanced staining at cell-cell junctions, and weak or no surface staining is seen on normal ductal cells. Nr-CAM expression is markedly up-regulated in intraductal hyperplasia. Expression was well maintained in well or moderately differentiated carcinoma but was reduced or absent from most poorly differentiated tumors. In addition, 4 of 4 human pancreatic adenocarcinoma cell lines tested demonstrated little or no Nr-CAM expression. This differential regulation of Nr-CAM expression suggests that it may be involved in the pathogenesis and invasive/metastatic behavior of pancreatic cancers. HUM PATHOL 32396-400.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreas
/
Pancreatic Neoplasms
/
Cell Adhesion Molecules
Limits:
Humans
Language:
En
Journal:
Hum Pathol
Journal subject:
PATOLOGIA
Year:
2001
Document type:
Article
Affiliation country: