Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity.

Schann, S; Bruban, V; Pompermayer, K; Feldman, J; Pfeiffer, B; Renard, P; Scalbert, E; Bousquet, P; Ehrhardt, J D

Schann, S; Bruban, V; Pompermayer, K; Feldman, J; Pfeiffer, B; Renard, P; Scalbert, E; Bousquet, P; Ehrhardt, J D.

Affiliation

Schann S; Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Université Louis Pasteur, Faculté de Médecine, 11, rue Humann, 67000 Strasbourg, France.

J Med Chem ; 44(10): 1588-93, 2001 May 10.

Article in En | MEDLINE | ID: mdl-11334568

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazoles / Pyrroles / Receptors, Drug / Cyclopropanes / Antihypertensive Agents Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2001 Document type: Article Affiliation country: Country of publication:

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